Effects of polysaccharide and phycocyanin from spirulina on peripheral blood and hematopoietic system of bone marrow in mice.by Zhang Cheng-Wu, et al.. April 1994. Nanjing Univ. China. Pub. in Proc. of Second Asia Pacific Conf. on Algal Biotech. Univ. of Malaysia. China.
and polysaccharide were isolated and purified from spirulina. By using
the techniques of colony forming unit-erythroid (CFU-E) culture of fetal
liver cells in mice in vitro, C-phycocyanin was found to possess high
erythropoietin (EPO) activity. The effects of polysaccharide and
phycocyanin on the periphyeral blood and bone marrow hematopoietic stem
and progentitor cell in normal, irradiated and anemic mice were studied.
These studies demonstrate the unique capacity of C-phycocyanin and
polysaccharide to influence the differentation and proliferation of
committed hematopoietic progenitor cell. Stimulated recovery by C-phycocyanin and polysaccharide was observed in leukocyte and bone
marrow nucleated cell counts and the number of CFU-GM colony formation
in mice after single whole-body gamma-ray irradiation. The C-phycocyanin
and polysaccharide can lower the anemic degree of mice combined with
treatment of gamma-ray irradiation and benzohydrazine hydrochloric acid
Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.
Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC.
Department of Molecular Pharmacology and Physiology, College of Medicine, University of South Florida, Tampa, Florida, United States of America. May 2010
Adult stem cells are present in many tissues including, skin, muscle, adipose, bone marrow, and in the brain. Neuroinflammation has been shown to be a potent negative regulator of stem cell and progenitor cell proliferation in the neurogenic regions of the brain. Recently we demonstrated that decreasing a key neuroinflammatory cytokine IL-1beta in the hippocampus of aged rats reversed the age-related cognitive decline and increased neurogenesis in the age rats. We also have found that nutraceuticals have the potential to reduce neuroinflammation, and decrease oxidative stress. The objectives of this study were to determine if spirulina could protect the proliferative potential of hippocampal neural progenitor cells from an acute systemic inflammatory insult of lipopolysaccharide (LPS).
Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae.
Romay C, Armesto J, Remirez D, González R, Ledon N, García I.
Pharmacology Department, National Center for Scientific Research, CNIC, Havana, Cuba. firstname.lastname@example.org
Nutraceuticals synergistically promote proliferation of human stem cells.
Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA. email@example.com
A viable alternative to stem cell transplantation is to design approaches that stimulate endogenous stem cells to promote healing and regenerative medicine. Many natural compounds have been shown to promote healing; however, the effects of these compounds on stem cells have not been investigated. We report here the effects of several natural compounds on the proliferation of human bone marrow and human CD34(+) and CD133(+) cells. A dose-related effect of blueberry, green tea, catechin, carnosine, and vitamin D(3) was observed on proliferation with human bone marrow as compared with human granulocyte-macrophage colony-stimulating factor (hGM-CSF). We further show that combinations of nutrients produce a synergistic effect to promote proliferation of human hematopoietic progenitors. This demonstrates that nutrients can act to promote healing via an interaction with stem cell populations.